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KMID : 1100220060050010001
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Dementia and Neurocognitive Disorders
2006 Volume.5 No. 1 p.1 ~ p.4
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MR Perfusion Imaging of Alzheimer’s Disease with Arterial Spin Labeling (ASL)
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Kim Sung-Tae
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Abstract
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Over the past decade, magnetic resonance imaging (MRI) methods have been developed that are sensitive to functional changes and provide resolution and contrast comparable with or exceeding that obtained with nuclear medicine techniques, without the use of ionizing radiation. Images sensitive to blood volume, blood oxygenation, and blood flow are now being routinely used for activation studies and the clinical evaluation of stroke and neoplasms. Such MRI techniques could be advantageous for studies of Alzheimer’s disease (AD), because MRI is more widely available than PET, has higher spatial resolution than SPECT, and can produce high resolution, spatially coregistered, structural images. Blood flow MRI by arterial spin labeling uses electromagnetic labeling of the naturally existing water in the blood to acquire images sensitive to flow without any external contrast agents. Recent technical advances have made the acquisition of multiple slices and absolute quantification possible. Basic principle of arterial spin labeling technique and recent works on this technique in AD will be reviewed.
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KEYWORD
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Alzheimer’s disease, Arterial spin labeling, Magnetic resonance imaging
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